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phenobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may possibly increase the metabolism of ifosfamide to its Energetic alkylating metabolites.Monitor Carefully (1)somatropin will lessen the level or outcome of phenobarbital by impacting hepatic/intestinal enzyme